CURCUMIN NANOPARTICLES VERSUS CURCUMIN IN AMELIORATION OF INFLAMMATORY AND PATHOLOGICAL CHANGES DURING THE MIGRATORY PHASE OF MURINE TRICHINELLOSIS

Trichinella spiralis can cause systemic inflammatory manifestations all over the body beforehabituating their destination in striated muscles. Its new borne larvae (NBL) most dangerousphase go via bloodstream of different organs during migration.This study explored anti-inflammatory, antioxidant and anti-apoptotic effects Curcumin(Cur) Curcumin nanoparticles (Cur-Nano) on pathological changes occurredin murine trichinellosis larval migratory phase.Forty (40) male Swiss albino mice were divided into four groups ten each. GI: miceinfected treated with Cur, GII: infected Cur-Nano, GIII: nontreatedmice (positive control) GIV: non-infected non-treated (negative control). Mice wereinfected orally 200 T. per mouse. GI & GII received treatment 13th daypost infection (dpi) for 5 successive days. All sacrificed 30th dpi. Effects Cur& Cur-Nano evaluated by counting encysted muscle light microscope.Frozen sera (-20°C) used quantitative estimation ALT, AST, TNF?, transforminggrowth factor-? (TGF-?) Troponin (Trop). Specimens lung, liver, brain heartwere fixed neutral buffered formalin H&E immunohistochemical staining.The results showed that number was significantlyreduced compared to GIII. In both (GI GII), there a significant reduction inmean levels TGF-?, Trop. There improvement bileduct injury proliferation, alveolar pleural inflammation, bronchial epithelial proliferation,as well as degenerative heart. The nontreatedgroup (GIII) overexpression Cyclooxygenase-2 (COX2), caspase 3,glial fibrillary acidic protein (GFAP), arginase granzyme b, low expressionof peroxisome proliferator-activated receptors (PPARs) groups.